BEST WEIGHT LOSS SUPPLEMENTS OF 2025
The world of weight loss is having a massive uptick with trending weight loss drugs, like Ozempic. While weight loss has always been a hot topic with diets, supplements are often overlooked. For decades people have spent billions of dollars on weight loss products to help them achieve their ideal body weight. It can be overwhelming to determine what are the best weight loss supplements, so, I rounded up a list for the best weight loss supplements of 2025. Last year, berberine was all the rage touted as “nature’s Ozempic”. This year, we’ve got a full list plus the best over the counter weight loss supplement recently launched as an alternative to high cost weight loss drugs!
Weight loss drugs and supplements are not intended to replace healthy eating and exercise, so be sure to combine these products with lifestyle changes to help you drop some pounds. Supplements can help support your weight loss journey.
With the New Year here find our best weight loss supplement round up!
Weight loss drugs and supplements are not intended to replace healthy eating and exercise, so be sure to combine these products with lifestyle changes to help you drop some pounds. Supplements can help support your weight loss journey.
With summer here, suit up with your swim trunks and bikinis and find our best weight loss supplement round up!
Category winners were chosen on a few different factors:
- Ingredients – I selected products with ingredients that support weight management or weight loss efforts and backed by science.
- Innovation – If you thought all weight loss supplements were created equal, think again! I’ve included a few products that take on healthy weight support on a whole new level.
- A well-rounded routine – I wanted to take this outside the box, and think about aspects of weight management, like muscle and blood sugar support that contribute to healthy body weights. Besides just losing pounds, how else can a supplement support weight loss? Learn more about a well-rounded routine for you here: Weight Loss & Weight Management and Weight Management Articles | GNC.
Here’s my list as a Registered Dietitian if you’re looking for a weight loss supplement.
TOP WEIGHT LOSS SUPPLEMENTS OF 2025
BEST OVERALL WEIGHT LOSS SUPPLEMENT
GNC Total Lean® - GlucaTrim™
Key Features
- Supplement Type: Pills
- How to use: Take twice daily before your biggest meals
- Benefit for Weight Loss Support: Multi-action weight loss support
Coming in at the best overall weight loss supplement is the newest formula to GNC’s Total Lean line. This is one of the most comprehensive formulas designed to be a multi-action weight support supplement. We deem this the best over the counter weight loss as it targets similar mechanisms as weight loss drugs.
As the best OTC weight loss product, it features ingredients with proven weight loss, blood glucose support, and caffeine free. I love the nature–inspired support shown to work together to target fat metabolism, protect lean mass, increase calorie burn, support blood sugar levels, and reduce inches from trouble areas!*^
One of the main ingredients, Slimvance® is a patented blend with several clinical studies (see Best non-stim supplement below for the deets). As a dietitian, I love the clinical evidence behind this nature-inspired blend of turmeric, moringa, and curry. I know it might sound too good to be true but check out the real results with people who used Glucatrim, formulated for maximum results!
BEST NON-STIM WEIGHT LOSS SUPPLEMENT
BodyDynamix® Slimvance® Core Slimming Complex Stimulant Free
Key Features
- Supplement Type: Pills
- How to use: Take twice daily
- Benefit for Weight Loss Support: Nature-inspired blend clinically proven to help you drop pounds and inches
Slimvance is the real MVP for a non-stim weight loss supplement. Not only is Slimvance clinically proven to help with weight loss, but it also won the “Weight Management Ingredient of the Year”, not once, but TWICE!
Slimvance is a blend of plant-based ingredients offered in several products within the BodyDynamix assortment, including our best otc weight loss supplement Glucatrim. The herbal botanical blend is unbeatable with clinically studied ingredients to help increase metabolism, lose inches and pounds.^* There have been several clinical studies to scientifically back this product. One of my favorite studies was a 7-day acute trial where a daily dose of 900 mg Slimvance burned on average nearly an extra 175 daily calories vs. the placebo with no changes to their daily routine.^* That’s almost as much as a 30-minute brisk walk!
The real power behind Slimvance comes from their long-term studies. When combined with a walking plan and 1800 calorie diet, Slimvance helped participants lose nearly 10 more pounds than the placebo group!^◊* If you love these ingredients but prefer a stimulant with your weight loss supplement, try Slimvance XP which has the same clinically studied botanical blend plus caffeine.
BEST PROTEIN POWDER FOR WEIGHT LOSS
GNC Total Lean® Lean Shake™ 25
Key Features
- Supplement Type: Powder
- How to use: Add a serving to your oatmeal, smoothies, or water
- Benefit for Weight Loss Support: Protein powder to help you feel fuller longer
The Total Lean® brand supports weight management across all aspects, whether you are maintaining your weight or trying to lose weight. You might be asking what is the best protein supplement for weight loss, and that’s Total Lean Lean Shake 25. This goes beyond a basic protein powder and provides 25 grams of protein and 7-8 grams of fiber per serving which will fuel your day and help keep you full! That’s the same amount of protein as four large eggs and fiber of two small apples!
You also get 22 vitamins and minerals that will help fill nutritional gaps on your weight loss journey. Other protein powders typically don’t have such a powerful punch of nutrients for just one scoop of protein. Other protein powders miss out on beneficial ingredients like fiber, vitamins, and minerals, all important for weight loss and maintenance.
You also get 22 vitamins and minerals that will help fill nutritional gaps on your weight loss journey. Other protein powders typically don’t have such a powerful punch of nutrients for just one scoop of protein. Other protein powders miss out on beneficial ingredients like fiber, vitamins, and minerals, all important for weight loss and maintenance.
BEST APPETITE CONTROL SUPPLEMENT
GNC Total Lean® Appetrex Control™
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Key Features
- Supplement Type: Pills
- How to use: take 30-60 minutes before lunch or dinner
- Benefit for Weight Loss Support: Appetite control support
Best appetite control was a no brainer. It’s been clinically shown to reduce calorie intake when taken once daily prior to lunch or dinner. After just one week of taking the supplement, participants reduced their calorie intake by nearly 10% versus the placebo.^* If this was extrapolated across the entire day with a diet consuming around 2,000 calories per day, that could be almost 200 calories less per day! While it doesn’t seem like much taken at face value, it adds up when it’s a long-term habit!
Best Blood Sugar Support Supplement
Key Features
- Supplement Type: Pills
- How to use: Take before your two biggest meals of the day
- Benefit for Weight Loss Support: Supports a normal, healthy blood sugar response.
As a dietitian, I know the importance of healthy blood sugar support for optimizing your health. Part of the reason why GLP-1 agonist weight loss drugs promote weight loss is insulin and blood sugar support. Maintaining healthy blood sugar isn’t always easy. Preventive Nutrition Health Blood Sugar Formula contains clinically studied Reducose® to help support a healthy blood glucose response* plus Chromium and Cinnamon Bark Extract, which are two ingredients shown to help blood sugar levels.* With a clinically studied ingredient plus two other ingredients known to support blood sugar levels, it’s a win for this category.
Best Water Balance Supplement
Key Features
- Supplement Type: Pills
- How to use: Take 4 capsules daily
- Benefit for Weight Loss Support: Help regulate water balance, improve bloating in as little as 7 days.
Excess water can lead to holding on to more pounds, and hello bloat. Another clinically studied ingredient, Bimuno® B-GOS® Galactooligosaccharides at 1.37g daily significantly improved bloating, gas, and digestive comfort after 7-days and 14-days.^* That’s just what you’re getting in the water pill formula! I don’t know about you, but if my gut feels bloated, and I’m not feeling great on my weight loss journey, a water pill can help!
Remember, everyone’s journey is unique, so finding the right weight loss supplement that suits your needs and preferences is key. GNC has tons of resources to help you with your weight loss journey and building a sustainable routine. With the right mindset and a holistic approach to weight loss, you’ll be well on your way to achieving your goals.
Best Weight Loss Supplements of 2025 Comparison Chart
Here’s a quick summary of the top weight loss supplements in terms of price per serving, dose, type, and key features.
*Retail prices as of Dec 2024
How Much Would a Sample Routine Cost per Month?
Remember, everyone’s journey is unique, so finding the right weight loss supplement that suits your needs and preferences is key. GNC has tons of resources to help you with your weight loss journey and building a sustainable routine. With the right mindset and a holistic approach to weight loss, you’ll be well on your way to achieving your goals.
At first glance, these supplements might seem costly, however with multiple benefits, the bang is certainly worth the bucks!! GNC often has BOGO specials where you buy one and get one 50% off, so even more cost savings!
Since some of the product benefits overlap, I picked a routine similar to how the weight loss drugs function with appetite and blood sugar support plus added complementary protein and HMB to support muscle health for a cost comparison.
While these supplements are not weight loss drugs, there is compelling evidence to support weight loss, and significant cost benefits for a weight loss journey! Whatever your journey is, GNC can provide support.
