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Welcome Offer! Standard priced items enjoy 5% OFF! Use code :【 WELCOME
* New member exclusive

Welcome Offer! Standard priced items enjoy 5% OFF! Use code :【 WELCOME
* New member exclusive
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GNC PRODUCT SERIES: A DEEP DIVE INTO GNC’S POWERFUL THERMOGENIC BLEND

GNCJun 16, 2025 • 4 min read

Did you know that GNC has invested in numerous clinical studies involving our top-selling products?

In this article, we’ll do a deep dive into one of GNC’s clinical studies where a powerful blend of thermogenic ingredients was put to the test. This clinical study fueled the inclusion of our thermogenic blend into the GNC Mega Men®, GNC AMP Wheybolic®, and GNC Total Lean® family of products.

“Thermogenesis” refers to the production of heat. From a physiological standpoint, individuals seek ways to increase thermogenesis in the body with the desire to burn more calories, boost energy levels, and increase fat loss. There are dietary supplements known as “thermogenics” that are marketed to accelerate these metabolic functions.

Does a thermogenic actually work? Do you really burn more calories? Are all thermogenics created equal? That’s what GNC researchers were set to find out.

WHAT DID GNC STUDY?

A team of Scientists and Registered Dietitians at GNC formulated a state-of-the-art thermogenic blend, known as GNC X12™. This blend consisted of four ingredients: Capsicum, Bioperine (also known as black pepper), niacin, and caffeine. Researchers wanted to understand how this unique blend of ingredients would influence calorie burning before, during, and after exercise.

WHAT WAS THE OBJECTIVE OF THE STUDY?

The goal of this study was to determine if GNC X12™ would impact calorie burn following one-hour of walking on a treadmill at a low intensity. After subjects consumed the thermogenic blend or a placebo, measurements capturing heart rate, blood pressure, and energy expenditure were measured at various time points. The study was performed in a controlled environment before, during, and following activity on two separate occasions. Researchers believed their expertly curated GNC X12™ product would enhance calorie burn when compared to the placebo.

WHO WERE THE STUDY PARTICIPANTS?

Volunteers were representative of GNC’s customer base – 28 men and women in good physical health.

Study Design

GNC chose a randomized, double-blind placebo-controlled crossover study with two treatment arms: GNC X12™ vs. placebo. A double-blinded study design eliminates bias as both researchers, staff, and volunteers are unaware of which product was received. Subjects walked on a treadmill on separate occasions, on one occasion they took GNC X12 and on the other, a placebo.

WHAT WERE THE RESULTS OF THE STUDY?

Researchers found changes over a 180-minute window, pre- to post-exercise, when volunteers received the GNC X12™. Here’s a breakdown of these impressive results:

BURN MORE CALORIES^

  • On average, participants burned 3 times more calories before exercise, and experienced 12 times more calorie burning after their workouts.
  • Helps burn a total of 278 more calories from pre-workout, during, and post-workout when compared to placebo alone.

WHAT DOES THIS MEAN?

GNC’s X12 thermogenic has been clinically proven and shown to help burn 12 times more calories when compared to a placebo following exercise. This increase in calorie burn improves metabolism before, during and after exercise, which helps burn a total of 278 more calories when compared to placebo alone.^

So what’s the bottom line? GNC’s X12 blend helps you get more out of your workouts and can even help you to burn more calories with exercising!

Interested in reading the full clinical study? It’s been published in the Journal of Strength and Conditioning Research.

WHERE CAN I PURCHASE THIS THERMOGENIC BLEND?

GNC’s thermogenic blend can be found in select GNC products, such as:

^ In a double blind, randomized, placebo controlled cross-over study, 28 subjects exercised on a treadmill on two occasions. On one occasion the subjects took this blend before exercise and on the second occasion, they took a placebo. When the subjects took this blend, they burned three times more calories before, 3% more calories during and 12 times more calories, after exercise amounting to a total of 278 calories compared to when they took the placebo.

GNC
Author: GNC

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