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INGREDIENT DEEP DIVE – VELOSITOL

GNCDec 15, 2025 • 3 min read

t workout and post recovery experience.

READ MOREWhy is Muscle Recovery so Important?

WHAT DOES THE RESEARCH SAY ABOUT VELOSITOL?

In a human clinical study, Velositol has been shown to significantly enhance muscle protein synthesis. In a double-blind crossover study, ten subjects were randomly assigned to one of two groups: 6g whey protein + 2g of Velositol® or 6g whey protein alone. Protein turnover, through fractional synthesis rate (FSR), was measured to assess MPS. Results demonstrated that in the Velositol group, FSR increased 48% from baseline – a significant difference from the control group.

In a second double-blind cross-over design clinical study, subjects consumed a beverage containing 6g whey protein or 6g whey protein + 2g of Velositol and then completed 8 sets of bilateral isotonic leg extensions. Results showed that when Velositol was combined with whey protein, it increased levels of myokines. Myokines are proteins released by skeletal muscle fibers in response to muscular contraction during exercise and are involved in promoting muscle growth. Additionally, myokine levels were highest in the subjects receiving Velositol + whey protein.(2) These results showed that Velositol, when combined with whey protein, helps promote muscle growth.

WHAT MAKES VELOSITOL UNIQUE?

Velositol is different from other ingredients because it can provide benefits to both active and inactive individuals. Velositol can significantly increase MPS when added to whey protein. These increases were significantly greater than whey protein alone.

WHO CAN BENEFIT FROM VELOSITOL?

If you’re looking to maximize muscle growth and strength, incorporating Velositol into your workout regimen can help support your fitness goals. Velositol benefits include the potential for the acceleration of muscle protein synthesis to give it consumers extra support as part of an exercise program. You can find Velositol® in GNC AMP Wheybolic™ Whey Protein – our clinically proven performance protein powder. Keep your eyes out for this standout ingredient in future products to enhance training and help to achieve your performance goals.

References

1. Ziegenfuss, T. N., Lopez, H. L., Kedia, A., Habowski, S. M., Sandrock, J. E., Raub, B., … & Ferrando, A. A. (2017). Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein. Journal of the International Society of Sports Nutrition, 14(1), 6.
2. Ziegenfuss, T. N., Cesareo, K., Raub, B., Kedia, A. W., Sandrock, J. E., Kerksick, C. M., … & Lopez, H. L. (2021). Effects of an Amylopectin-Chromium Complex Plus Whey Protein on Strength and Power After Eight Weeks of Resistance Training. Journal of Exercise and Nutrition, 4(3).

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